Clint is an omega who isn't interested in mating. Ever. That doesn't mean he wouldn't like a romantic partner, though. Unfortunately, he's never found anyone who was okay with the whole lack of interest thing... but there might be hope yet.

“I don’t understand why everyone is so obsessed with sex!” Loki burst out. "There are far more interesting things."

The first thing Tony says when they come down to breakfast the morning after moving into the Tower is, “So, you two are together, right?”

Discovering that you have some kind of angel-marriage, soulbond-thing to your nerdy angel friend kind of forces you to re-evaluate your relationship. In Dean's case, this involves freaking out and massive fail.

"Sorry, you have me confused with the other angel. You know, the one in the dirty trench coat who's in love with you." Dean and Castiel finally have that conversation.