Madara lied about the eye transplant's effects. Captured and brought back to Konoha, Sasuke must adjust to blindness and his unexpected survival. (One main story with two sidefics.)

Naruto gets his hands on the key to his seal too early, and the yang and yin chakra of Kyuubi are freed. As in, now there are three Narutos.

Itachi and Madara massacre the clan, but they miss one member. Obito, loyal Konoha ANBU and disowned Uchiha, suddenly finds himself out of the organization that’s been his life for eight years and raising a traumatized, orphaned child. Kakashi helps. Or watches and plays the smartass, it’s a bit of a tossup.

A super-cracky modern!AU where Akatsuki is a group of quasi-reformed terrorists and former suicide squad now (nominally) on the side of the angels, saving the planet their own way. Mostly accidentally. Or through recycling. (That's entirely Obito's fault.)