Karkat Vantas, despite numerous protests, has just joined Alternia High's Gay-Straight Alliance. Shenanigans ensue.

You haven't ever felt bad to pail a brother or sister before, but for some reason you look down on his strange, angry, nubby-horned little face and it hurts inside you, hurts like a motherfucker. In a universe where the hemospectrum is long-abolished but never forgotten and the descendants of ancient rebels are looked to as the leaders, a tired purple-blood drowning in his drugs find a lonely mutant on the run from his bloodline, in the wrong place, for all the wrong reasons. Series