Phil Coulson is miserable, distrusted by most of SHIELD, and still doesn't remember why. It's only going to get worse before it gets better.

Something strange happened to Wade. Well, something strange always happens to Wade. But this type of strange involves an alien ray, Wanda (aka Lady Deadpool), and some slight errors with his regeneration in another universe. Luckily, the Merc with the Mouth has an Ultimate Amazing boyfriend and a newly adopted sister/doppelganger to help him through. Or Deadpool is atomized, and comes back home with lady parts.